Plague of Toads

Plague of Toads is a Poison spell used by Witch Doctors in Diablo III.

In-game
Releases four toads that leap erratically roughly 60 yards forward (may turn aside if it encounters a piece of impassable terrain), in a cone no wider than 90 degrees. If a toad collides with an enemy, it explodes, dealing Poison damage to one victim. Toads die in 3 seconds.

Runes:

 * Explosive Toads: damage type changes to Fire, damage increases to 245%.
 * Piercing Toads: damage type changes to Physical, damage is reduced to 130%, but toads now pierce through enemies instead of only exploding once.
 * Rain of Toads: instead of usual effect, creates a rain of toads at the targeted area that deals 182% damage as Poison to enemies within 5 yards radius over 2 seconds.
 * Addling Toads: each enemy hit has a 15% chance to be d for 4 seconds.
 * Toad Affinity: damage type changes to Cold and gain 9 Mana every time a toad hits an enemy.

Non-rune enhancements:

 * Rhen'ho Flayer (Legendary Ceremonial Knife): toads home at enemies (turning aside if necessary) and explode twice (after hitting an enemy, continue moving, but cannot hit the same target again).
 * Depth Diggers (Legendary Pants): damage increases by 80-100% (Toad Affinity Rune only).
 * Simplicity's Strength (Legendary Gem): increases damage by 25% (+0.5% per rank) and heals the character for 4% of maximum Life per hit (rank 25 bonus).
 * Boyarsky's Chip (Legendary Gem): Taunts the first enemy hit for 2 seconds (rank 25 bonus).
 * Helltooth Harness Set (Set Bonus for 2 items): damaging enemies with Plague of Toads will apply Necrosis, slowing enemies by 60% and inflicting 3000% damage per tick for 10 seconds. Elemental Damage type is chosen from the highest skill bonus of the character.
 * Helltooth Harness Set (Set Bonus for 6 items): after casting Wall of Death, gain +9000% increased damage for 15 seconds for Plague of Toads.
 * Spirit of Arachyr Set (Set Bonus for 6 items): increases damage by 17500%.

Passives:

 * Vision Quest: every damaging hit increases Mana regeneration by 40% for 5 seconds, effect does not stack.

Trivia

 * The name of the spell is a reference to the Biblical second plague of Egypt: the incursion of frogs.