Gem of Efficacious Toxin

Gem of Efficacious Toxin is a Legendary Gem in Diablo III. It can only be socketed into Amulets and Rings, and drops from Greater Rift Guardians.

This gem causes any attacked enemy (regardless of the Proc Coefficient of the attack, skill or spell) to suffer Poison damage over time. This effect is renewed by further attacks, but does not stack. Upgrading increases the total damage done (and the damage per second).

At rank 25, it also increases all damage that the poisoned target takes from all sources (including other players), making this gem useful to classes focusing on elements other than Poison. The debuff does stack from multiple players (see example video). In addition, affected foes also deal less damage with all attacks, also stacking from multiple players.

Any damaging attack made by the player character or their pets will apply the poison. However, it will only be applied on cast. As a result, DoT effects will not refresh the poisoning.

Also note that Raiment of the Jade Harvester Set bonus does consume the Gem of Efficacious Toxin effect, but does not apply the new poisoning. As this gem does not benefit from Creeping Death and Quetzalcoatl, the damage bonus is less than it could be, however.

Since this gem uses Poison damage, the only classes that can potentially enhance it with elemental damage skill bonuses are the Witch Doctor and the.

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The poison mixers of Xiansai tell of a sickly gem cutter named Zhong Yi Rou who would come by their vats and scream "I'll put you all out of work someday! Yes I will!"