Flayed One (Diablo III)

"These poor thing live in eternal torment. I feast on their agony...Their eternal anguish...The chains tear at their flesh... Hear their screams. Such sweet music."

- Cydaea

Flayed Ones were large demons that were tortured and their skin torn off to be used to create structures. They were kept in a state of perpetual torment, screaming as chains tore their flesh.

The Nephalem saw them whilst traveling through the sin towers in the Arreat Crater.

In-game
Flayed Ones appear in the Arreat Crater zone in Diablo III. However, they appear purely in the background. They are only properly named and described by Eirena if she acts as a follower in the zone.